Abstract: Type 1 diabetes mellitus (T1DM), an autoimmune disorder, is becoming widespread with approximately 97,700 children in India and 490,000 children worldwide affected. There are various etiological factors contributing to the expansion of its incidence in different geographical locations. Hence, the articles published in reputed journals were studies and data was collected for analyzing the aetiology and prevention of T1DM. It has been observed that hybrid insulin peptides act as key antigens for the autoreactive T cells and causes loss of self-tolerance in humans. The association of coxsackievirus B has been observed with the onset of T1DM. Accurate identification of the trigger can lead to the development of appropriate preventive measures. It can become a base for advanced studies to prevent T1DM in humans. This review will highlight the causes and some preventive actions which can be considered to eliminate T1DM.
Journal: Current Diabetes Reviews
Keywords: Type 1 diabetes mellitus; coxsackievirus B virus; etiology; pathogenesis; prevention
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